Back to Poster Index Page

Active Human Herpesvirus Six and Multiple Sclerosis: Clinical Treatment and Relationships

K.K. Knox¹, L.J. Lobeck², E.F. Maas², and D.R. Carrigan¹. 
Institute for Viral Pathogenesis¹, 10437 Innovation Drive, Milwaukee, WI 53226
Wisconsin and Department of Neurology, Medical College of Wisconsin², 9200 W Wisconsin Ave, Milwaukee, WI 53226

Presented at the 54th American Academy of Neurology Annual Meeting; April 2002

 Abstract

Several laboratories, including our own, have presented data linking the pathogenesis of MS to active HHV-6 infections. Blood samples were obtained at the time of new clinical relapse in patients with relapsing-remitting MS and assessed for active HHV-6 infection by plasma PCR.  Then, several weeks later (mean interval:68 days), a second blood sample was obtained from the same patients and assessed for active HHV-6 infection.  Patients' changes of Expanded Disability Status Scale (EDSS) from the relapse and treatments at the time samples were obtained were noted.  Five of 39 (13%) patients had at least one sample positive for active HHV-6 infection. Variant typing of the positive samples was possible with 3 of the 5 positives, and 2 were HHV-6 variant A.  Four of the five (80%) positive samples were obtained at the time of relapse whereas only one (20%) positive was observed in a patient after relapse.  The HHV-6 positive patients suffered a larger change in their EDSS (mean EDSS change of 1.4) than the HHV-6 negative patients (mean EDSS change of 0.7). It was also found that the patients receiving either beta interferon or glatirimar acetate (copaxone) were less likely to be HHV-6 positive (2/30; 7%) than the patients receiving no treatment 3/9; 33%).  Since the majority (>75%) of the patients on therapy were receiving  beta interferon, the decreased positivity for active HHV-6 may reflect the known antiviral properties of beta interferon.

Introduction

Patients And Methods

Patients and Controls

Detection of Active HHV-6 Infections by Plasma PCR

Results

wpe1.gif (25118 bytes)

Click thumbnail to view larger version of figure.


Characteristics of the MS patients who were positive for active HHV-6 Infection by plasma PCR (Table Below).

wpe6.gif (25247 bytes)

Click thumbnail to view larger version of figure.


Relationship Between Positivity for Active HHV-6 Infection by Plasma PCR and Treatment Regimens

wpe7.gif (23433 bytes)

Click thumbnail to view larger version of figure. 


Relationship Between Positivity for Active HHV-6 Infection by Plasma PCR and Change in EDSS score by Disease Relapse

wpe8.gif (24358 bytes)

Click thumbnail to view larger version of figure.


Relationship Between Tumor Necrosis Alpha (TNFa) And Active  HHV-6 Infection in MS Patients

Conclusions

The major findings of these studies can be summarized as follows:

 

TOP


© 2001-2005 Institute for Viral Pathogenesis. All rights reserved.